Volume 24, Issue 114 (7-2014)                   J Mazandaran Univ Med Sci 2014, 24(114): 186-206 | Back to browse issues page

XML Persian Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Badali H, Khodavaisy S, Mohammad Davoudi M, Biranvand E, Mardani M. Antifungal Therapy for Invasive Fungal Infections. J Mazandaran Univ Med Sci. 2014; 24 (114) :186-206
URL: http://jmums.mazums.ac.ir/article-1-3935-en.html
Abstract:   (9109 Views)
Recently, despite the application of surgery and antifungal therapy, mortality rate of invasive fungal infections due to opportunistic fungi such as Candida and Aspergillus species has dramatically increased specially in immunocompromised host. The status of the immune system plays a key role in controlling the disease, yet antifungal therapy is of great benefit in saving involved patients. Today some efficient antifungal agents are available which are very expensive compared to amphotericin B deoxycholate. The empiric treatment of Candida bloodstream infections is fluconazole therapy which is the best choice for neutropenic patients with and without septic shock. However, amphotericin B deoxycholate and caspofungin therapy are the optional treatments for patients who previously used azole agents. These drugs are considered as the first choice of treatment in patients with neutropenia. Fluconazole therapy is recommended for fungal infections due to C. albicans, C. tropicalis and C. parapsilosis and amphotericin B deoxycholate or caspofungin are applied for C. glabrata and C. krusei. Primary teherapy for invasive aspergillosis includes combination therapy in critically ill patients. Voriconazole and caspofungin (if not used as primary treatment) and liposomal amphotericin B are recommended in patients resistant to conventional treatments. Moreover, combination therapy with caspofungin with voriconazole and liposomal amphotericin B should be considered in severely ill patients. In clinical decision making clinicians should consider the results of different studies and also the cost of treatment.
Full-Text [PDF 290 kb]   (1423 Downloads)    
Type of Study: Research(Original) | Subject: mycology

Add your comments about this article : Your username or Email:
CAPTCHA code

Send email to the article author


© 2018 All Rights Reserved | Journal of Mazandaran University of Medical Sciences

Designed & Developed by : Yektaweb