Volume 24, Issue 118 (11-2014)
J Mazandaran Univ Med Sci 2014, 24(118): 73-82 |
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Akhavan Niaki H, Shomali T, Asouri M, Hashemi S M, Haghi H, Khorshidi M, et al . Association between Vitamin D Receptor Gene Fok1 Polymorphism and Bone Mineral Density in a Population of Postmenopausal Women with Osteoporosis. J Mazandaran Univ Med Sci 2014; 24 (118) :73-82
URL: http://jmums.mazums.ac.ir/article-1-4652-en.html
URL: http://jmums.mazums.ac.ir/article-1-4652-en.html
Haleh Akhavan Niaki 
, Tayebeh Shomali , Mohsen Asouri , Seyed MohammadBagher Hashemi , Hamed Haghi , Mohammad Khorshidi , Ramin Ataee * , Ali Asghar Ahmadi , Saeid Kavosian , Galia Amirbozorgi
, Tayebeh Shomali , Mohsen Asouri , Seyed MohammadBagher Hashemi , Hamed Haghi , Mohammad Khorshidi , Ramin Ataee * , Ali Asghar Ahmadi , Saeid Kavosian , Galia Amirbozorgi
Abstract: (8917 Views)
Background and purpose: Osteoporosis is a multiple disease that is characterized by decrease in bone mass and bone strength. This decrease is more common in postmenopausal women due to decreased estrogen levels. Vitamin D3 plays a pivotal role in skeletal metabolism by binding to nuclear steroid receptors (receptors for vitamin D (VDR)). This study aimed at investigating the relationship between Vitamin D3 receptor polymorphism and estrogen levels in postmenopausal women with severe osteoporosis.
Material and methods: The study population were 173 women including 91 postmenopausal women with osteoporosis and 82 women without osteoporosis (control group) aged 45-60 years of old. The study was carried out during 2011-2012. After extraction of genomic DNA from peripheral blood, FokI polymorphism (rs2228570) of the Vitamin D Receptor Gene (VDR) was investigated using polymerase chain reaction with restriction enzyme digestion (PCR-RFLP) method. Also, its relationship with bone mineral density (Bone Mineral Density) BMD, T-score, and Z-score was investigated.
Results: According to the results, there was no association between rs2228570 and osteoporosis. We observed significant differences in bone density between the two groups (P<0.001).
Conclusion: According to the findings, the association between genotype polymorphisms of vitamin D3 and osteoporosis is still unknown and other polymorphisms might affect bone density.
Type of Study: Research(Original) |
Subject:
Medicinal Chemistry
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