Volume 24, Issue 121 (2-2015)                   J Mazandaran Univ Med Sci 2015, 24(121): 414-430 | Back to browse issues page

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Amjadi O, Abedini M, Rafiei A, Safaii S, Ajami A, Hosseinian A. Interferons in Autoimmune Diseases: Friend or Foe. J Mazandaran Univ Med Sci 2015; 24 (121) :414-430
URL: http://jmums.mazums.ac.ir/article-1-5196-en.html
Interferons in Autoimmune Diseases: Friend or Foe
Omolbanin Amjadi , Mahmoud Abedini , Alireza Rafiei , Samaneh Safaii , Abulghasem Ajami , Aref Hosseinian
Abstract:   (9701 Views)
Interferons (IFNs) are pleotropic cytokines with strong anti-viral and immunomodulatory properties. Their function is dependent to signaling pathway upon binding to IFN receptor. Both pro- and anti-inflammatory effects are seen in interferons-related immune responses. While, interferons are in direct correlation with autoantibodies production during autoimmunity, they have protective effects. This paradoxical role of interferons may impose on immunopathogenesis of autoimmune diseases and selecting appropriate medical strategies. Here, we will review the role of interferons in autoimmune diseases such as giant cell arteritis and describe a general overview on their dual role in autoimmune diseases including, systemic lupus erythematosus, multiple sclerosis, rheumatoid arthritis, and scleroderma.
Keywords: Interferons, autoimmune diseases, autoantibody, immune response
Full-Text [PDF 258 kb]   (8170 Downloads)    
Type of Study: Review | Subject: Immunology
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