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Controlling the release of drugs and other therapeutic molecules has great importance in novel drug delivery. Nanoparticulate systems have the ability to control drug release and increase the presence of these compounds in blood flow and could convey them to a specific position. Growth factors are endogenous peptide which begins cellular signals to regulate cellular activities. The main problem is the instability of these factors in bloodstream and lack of proper distribution in systemic administration. Nanoparticles mainly nanocarriers have the ability to overcome this problem and play a great role in intelligentization of tissue engineering because of their unique features, including the creation of physical protection and collaboration with the scaffolds and cells. Due to the increasing use of growth factors in healing damaged tissues, and their application in tissue engineering, in this article a number of nanoparticles useful for the release of growth factors with a few examples are reviewed.

Keywords: Nanoparticle, Growth factor, Controlled release

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