Study of Regulatory T cells in Patients with Crohn Disease - Journal of Mazandaran University of Medical Sciences
Volume 25, Number 131 (12-2015)                   J Mazandaran Univ Med Sci 2015, 25(131): 98-107 | Back to browse issues page


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Khalili A, Mohammadnia-Afrouzi M, Maleki I, Hosseini V, Taghvaei T, Hossein-Nattaj H et al . Study of Regulatory T cells in Patients with Crohn Disease. J Mazandaran Univ Med Sci. 2015; 25 (131) :98-107
URL: http://jmums.mazums.ac.ir/article-1-6575-en.html

Abstract:   (1895 Views)

Background and purpose: Crohn disease (CD) is an autoimmune disorder in which a failure of tolerance to the intestinal antigens plays a pivotal role in the pathogenesis of this disease. Treg cells control immune responses to self and foreign antigens and have an important role in maintaining self-tolerance. In this study we evaluated the frequency of Tregs in the peripheral blood of patients with Crohn disease compared with healthy control group.

Materials and methods: In a case-control study, 18 patients with Crohn disease and 20 healthy volunteers were enrolled. Blood sampling was done in both patients and controls and peripheral blood mononuclear cells were isolated. Then, the frrequency of CD4+CD25+FoxP3+CD127low/– Tregs and CD4+CD25+FoxP3activated effector T cells were evaluated by flow cytometry. Data analysis was performed in GraphPad Prism and SPSS.

Results: The results showed that the frequency of Treg cells in the peripheral blood of CD patients was significantly lower compared to that of the healthy controls. In addition, a significant decrease in Treg/activated effector T cells ratio was observed in CD patients compared to controls.

Conclusion: The results showed that Crohn disease is associated with a decrease in the peripheral blood Tregs pool. Moreover, it seems that the balance between Tregs and effector T cells is disturbed in CD patients.

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Type of Study: Research(Original) | Subject: Immunology

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