Background and purpose: Overactive bladder symptoms are common in patients after prostatectomy. This study aimed at evaluating the effect of diltiazem plus tolterodine on overactive bladder symptoms.

Materials and methods: In a double blind randomized clinical trial conducted in 2013-2014, 80 men aged &ge65 years old with unresolved over active bladder symptoms after prostatectomy (in Kermanshah Imam Reza Hospital) who met our inclusion criteria were studied. They were randomly divided into two groups (n=40 per group) to receive either 60 mg bid diltiazem plus 2mg bid tolterodine/twice daily or 2mg bid tolterodine plus placebo/twice daily. The treatments continued for 4 weeks.

Results: The decrease in total score of International Prostate Symptom Score (IPSS) was not significantly different between the two groups (P> 0.05). Voiding frequency significantly improved in diltazem plus tolterodine group (P< 0.05). Mouth dryness was not significantly different between the two groups.

Conclusion: Diltiazem plus tolterodine treatment is associated with a significant improvement in reducing the symptoms of overactive bladder and could be used as a reasonable treatment option in older patients.