Volume 21, Issue 83 (Jul 2011)
J Mazandaran Univ Med Sci 2011, 21(83): 17-23 |
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Habibi M, Zamani A, Moslemizadeh N, Rezaei M, Shahmohammadi S, Peyvandi S. Comparing the Effect of Two Different Doses of Remifentanil Infusion on Apgar Score of the Neonates and the Mothers' Awareness During General Anesthesia Under Elective Cesarean Section. J Mazandaran Univ Med Sci 2011; 21 (83) :17-23
URL: http://jmums.mazums.ac.ir/article-1-685-en.html
URL: http://jmums.mazums.ac.ir/article-1-685-en.html
Abstract: (15810 Views)
Background and purpose: Remifentanil is a short-acting opiod that is metabolized rapidly in the fetus despite its rapid passage through the placenta. Therefore, it induces less adverse effects on the fetus. The aim of this study was to compare the effect of two different doses of remifentanil infusion on Âpgar score of neonates and mothers' awareness during general anesthesia in elective Çesarean section.
Materials and methods: This double-blind clinical trial was performed on 90 participants aged 18-35 years who were candidates for elective Çesarean section. They were randomly allocated into three equal groups as follows: the first case group received a remifentanil infusion of 0.2 µg/kg/min, the control group was infused with the same volume and rate of normal saline, finally, the second case group received a remifentanil infusion of 0.1 µg/kg/min. Âpgar scores of neonates were recorded in the 1st and 5th minutes after birth. Systolic and diastolic blood pressure and heart rates of mothers were recorded before induction, just before and after tracheal intubation and 5 min after that. Data were analyzed using SPSS17 through t-test, ÂNÔVÂ test and Repeated measures.
Results: Ïn the case groups, systolic and diastolic blood pressure and heart rates of mothers before induction, one minute and five minutes after intubation and after fetus delivery were less than that of the control group and the differences among the groups were statistically significant (P<0.05). However, there were no significant differences between the mean of Âpgar scores of the neonates one minute and five minutes after birth (P>0.05).
Çonclusion: Ït seems that remifentanil has supportive and controlling effects on oscillatory changes in blood pressure and heart rate of mothers and also it does not have any significant adverse effects on the mother and the fetus. These findings support the widespread use of this systemic opioid in general anesthesia during Çesarean section.
Materials and methods: This double-blind clinical trial was performed on 90 participants aged 18-35 years who were candidates for elective Çesarean section. They were randomly allocated into three equal groups as follows: the first case group received a remifentanil infusion of 0.2 µg/kg/min, the control group was infused with the same volume and rate of normal saline, finally, the second case group received a remifentanil infusion of 0.1 µg/kg/min. Âpgar scores of neonates were recorded in the 1st and 5th minutes after birth. Systolic and diastolic blood pressure and heart rates of mothers were recorded before induction, just before and after tracheal intubation and 5 min after that. Data were analyzed using SPSS17 through t-test, ÂNÔVÂ test and Repeated measures.
Results: Ïn the case groups, systolic and diastolic blood pressure and heart rates of mothers before induction, one minute and five minutes after intubation and after fetus delivery were less than that of the control group and the differences among the groups were statistically significant (P<0.05). However, there were no significant differences between the mean of Âpgar scores of the neonates one minute and five minutes after birth (P>0.05).
Çonclusion: Ït seems that remifentanil has supportive and controlling effects on oscillatory changes in blood pressure and heart rate of mothers and also it does not have any significant adverse effects on the mother and the fetus. These findings support the widespread use of this systemic opioid in general anesthesia during Çesarean section.
Type of Study: Research(Original) |
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