Volume 15, Issue 50 (Jan 2006)                   J Mazandaran Univ Med Sci 2006, 15(50): 139-142 | Back to browse issues page

XML Persian Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Ënayati A, Ladonni H. Mixed function oxidases and insecticide resistance in medically important insects. J Mazandaran Univ Med Sci 2006; 15 (50) :139-142
URL: http://jmums.mazums.ac.ir/article-1-725-en.html
Abstract:   (31784 Views)
MFÔs are a large diverse superfamily of enzymes found in all insect tissues. They are involved in the metabolism of xenobiotics (e.g. drugs, pesticides and plant toxins) and endogenous compounds (e.g. ecdysteroids and juvenile hormones). They are also involved in bioactivation of phosphorothioate compounds such as organophosphorus insecticides. They have very diverse activities like hydroxylation, epoxidation, N-, Ô-or S-dealkylation, deamination, sulfoxidation, desulfuration and oxidative dehalogenation. Their diverse functions are achieved through diversity in structure. There are over 100 P450 genes in the Drosophila genome, usually arranged in family clusters. MFÔ-mediated insecticide metabolism is a common mechanism by which insects become resistant to insecticides. Ïn this mini review article the role of oxidases in insecticide resistance is briefly discussed.
Full-Text [PDF 183 kb]   (4675 Downloads)    
Type of Study: Research(Original) |

Add your comments about this article : Your username or Email:
CAPTCHA

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2024 CC BY-NC 4.0 | Journal of Mazandaran University of Medical Sciences

Designed & Developed by : Yektaweb