Background and purpose: Diabetes causes adverse effects on the activity of reproductive system, including impaired spermatogenesis, decreased sperm count, testosterone serum, seminal fluid volume, and loss of sexual desire. The aim of this study was to evaluate the effect of E.cyparissias extract on tissue changes of prostate and vesicle seminal in diabetic rats.
Materials and methods: Thirty male Wistar rats were randomly selected and divided into three groups (n=10), including a control group (healthy animals), a diabetic group and a treatment group. Diabetes was induced by streptozotocin in treatment group and the animals received E.cyparissias extract (500 mg/kg) for 28 days by oral gavage. Then, the samples of prostate and vesicle seminal tissue were taken and prepared for histological study using light microscope.
Results: Morphology findings showed increase in secretion and in diameter of tubules and decrease in interstitial space of prostate and vesicle seminal in treatment group compared with those of the diabetic group. Histomorphometric results indicated significant increases in epithelium height, diameter of the tubules of the prostate and thickness of the muscle layer of seminal vesicles in treatment group compared with those in diabetic group (P˂0.05). The study also revealed that gland weight to body weight in treatment group increased significantly compared with that of the diabetic group (P˂0.05).
Conclusion: According to current findings, oral administration of E.cyparissias extract prevented diabetic induced tissue changes in prostate and seminal vesicle in rats.