Volume 26, Issue 142 (11-2016)                   J Mazandaran Univ Med Sci 2016, 26(142): 138-127 | Back to browse issues page


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Mansouri B, Maleki A, Davari B, Johari S A, Shahmoradi B, Mohammadi E. Effect of Subchronic Exposure of CuO NPs in Presence of TiO2 NPs on Fish Model. J Mazandaran Univ Med Sci. 2016; 26 (142) :138-127
URL: http://jmums.mazums.ac.ir/article-1-8793-en.html

Abstract:   (1891 Views)

Background and purpose: Simultaneous exposure of nanoparticles can cause serious damage to aquatic organisms including fish. The aim of this study was to investigate the toxicity effect of subchronic exposure of copper oxide nanoparticles (CuO NPs) in presence of titanium dioxide nanoparticles (TiO2 NPs) on the histopathology of gill and kidney tissues of fish model in vivo exposure.

Materials and methods: In this study, one non-lethal concentration of TiO2 NPs, two non-lethal concentrations of CuO NPs, two concentrations of TiO2 NPs and CuO NPs mixture, and a control group (no chemicals) were used. After 10 days of exposure to these materials, samples of gill and kidney tissues were collected. In order to study classical histology the samples were prepared by hematoxylin-eosin staining and the slides were photographed by optical microscopy.

Results: The damages caused in gill were as following: secondary curved blades, increased mucus secretion, increase in the agglomeration of secondary lamellae, and aneurism and hyperplasia. Also, blood vessels dilation, vacuoles, necrosis, focal tubule degeneration, and increase in melano-macrophage were observed in kidney tissue of common carp.

Conclusion: The study suggested that toxic effects of CuO NPs on tissues of common carp in the joint presence of TiO2 NPs were synergistic.

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Type of Study: Research(Original) | Subject: health

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