Volume 26, Number 143 (12-2016)                   J Mazandaran Univ Med Sci 2016, 26(143): 230-234 | Back to browse issues page


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Omrani-Nava V, Abediankenari S, Yazdani Charati J, Yahyapour Y, Shobeiri S S, Mohammadi M, et al . Evaluation of Human Leukocyte Antigen-G and Interleukin-10 Expression in HIV Positive Patients and Healthy Subjects. J Mazandaran Univ Med Sci. 2016; 26 (143) :230-234
URL: http://jmums.mazums.ac.ir/article-1-9011-en.html

Abstract:   (1701 Views)

Background and purpose: HILA-G is an immunomodulatory molecule and alteration of its expression is prevalent during viral infections. HLA-G expression in HIV-positive patients has been inconsistent between different studies and some suggest that Interleukin-10 (IL-10) influences the expression of HLA-G. The aim of this research was to investigate the expression of IL-10 in HIV-positive patients and its relation with TCD4+ lymphocytes.

Materials and methods: In a case-control study, 20 HIV-positive patients, attending the Behavioral Consultation Center affiliated with Mazandaran University of Medical Sciences, were selected and 20 healthy volunteers were also enrolled. Expression of HLA-G was determined by Real-Time PCR. TCD4+ count and IL-10 concentration were evaluated by flow cytometry and ELISA, respectively.

Results: HLA-G gene expression was significantly different between the two groups (P<0.05). IL-10 concentration increased in patients and a revers relation was seen between TCD4+ cell count and IL-10 (r= -0.4, P= 0.1).

Conclusion: The results showed that the expression of HLA-G is deregulated during HIV infection and IL-10 could be considered as a biomarker of disease progression.

Keywords: HLA-G, HIV, IL-10
Full-Text [PDF 531 kb]   (520 Downloads)    
Type of Study: Brief Report | Subject: Immunology

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