Volume 26, Issue 144 (1-2017)                   J Mazandaran Univ Med Sci 2017, 26(144): 144-151 | Back to browse issues page

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Mohammadi A, Hosseini-Fard R, Roustazadeh A, Naiafi M, Amirfarhangi A. Serum Level and rs1800799 Polymorphism of MGP Gene Promoter in Patients with Coronary Arteries Stenosis. J Mazandaran Univ Med Sci. 2017; 26 (144) :144-151
URL: http://jmums.mazums.ac.ir/article-1-9250-en.html
Abstract:   (2960 Views)

Background and purpose: Coronary artery stenosis is a progressive process associated with artery calcification. Although the role of matrix Gla protein (MGP) is not completely clear but its expression in vascular smooth muscle cells (VSMCs) and sub-endothelial macrophages suggests a role in vascular calcification. The rs1800799 is one of the polymorphisms oriented within transcription factor elements in the promoter region of the MGP gene that may modify MGP expression patterns resulting in artery calcification. In this study, we examined the serum level and rs1800799 polymorphism of MGP gene promoter in patients with stenosis of coronary artery in Tehran.

Materials and methods: One hundred sixty three individuals undergoing coronary angiography were divided into two groups: patients (n=100) and controls (n=63). The lipid profile, serum MGP concentration and rs1800799 genotypes were measured by routine laboratory, ELIZA, and RFLP-PCR assays, respectively.

Results: In this study, we observed positive relationships between the two groups in LDL, total cholesterol, and TG levels (P< 0.05). The HDL, BMI, history of renal disease, diastolic blood pressure and systolic blood pressure were not significantly different between the patients and controls (P> 0.05). Also, genotype and allele distributions did not differ significantly between the cases and controls (P> 0.05). Furthermore, the serum levels of MGP were not significantly different between genotypes (P> 0.1).

Conclusion: In this study, the rs1800799 genotype distribution and serum MGP value were not significantly associated with coronary heart disease. Moreover, the serum MGP level showed no major role in the progression of coronary artery stenosis.

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Type of Study: Research(Original) |

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