Volume 28, Issue 159 (4-2018)                   J Mazandaran Univ Med Sci 2018, 28(159): 1-13 | Back to browse issues page

XML Persian Abstract Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Ghaaazi Firozsalari F, Shahrokhi N, Khaksari Hadad M, Asadikaram G, Atashbar J. Effect of Shilajit on the Levels of Pro-inflammatory and Anti-inflammation Cytokines in Hepatic Injury in Male Rats . J Mazandaran Univ Med Sci 2018; 28 (159) :1-13
URL: http://jmums.mazums.ac.ir/article-1-9798-en.html
Abstract:   (25265 Views)

Background and purpose: Cytokines regulate a broad range of biological and pathological processes. They play an important role in liver damage. Inflammatory and antioxidant factors are important causes of liver damage. Shilajit is known as an anti-inflammatory and antioxidant agent. Therefore, the main aim of this study was to determine the effect of Shilajit on levels of proinflammatory and anti-inflammatory cytokines in liver injury.
Materials and methods: In this experimental study, 80 male Wistar rats were randomly divided into two main groups: A and B. Each group was organized into five subgroups: control, acetaminophen (A) or bile duct obstruction (BDL) (B), low dose, high dose, and vehicle. All subgroups except the controls in group A received 500 mg/ kg acetaminophen via IP injection, while BDL was performed in all subgroups in group B. Then in group A, two hours and  in group B seven days after injury, the treatment subgroups with drug and vehicle received 150 mg/kg (low dose) and 250 mg/kg (high dose)shilajit  and distilled water as vehicle, for one and six days, respectively. After completing treatment, liver samples were taken for laboratory analysis.
Results: Low-dose Shilajit treatment reduced IL-10, IL-6, IL-1β, and TNF- α levels, which had been increased by a single dose of 500 mg/kg acetaminophen (p<0.05).
Conclusion: Shilajit is effective in reducing inflammation and liver damage caused by high-dose consumption of acetaminophen.

Full-Text [PDF 1059 kb]   (2959 Downloads)    
Type of Study: Research(Original) | Subject: physiology

Add your comments about this article : Your username or Email:

Send email to the article author

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2023 CC BY-NC 4.0 | Journal of Mazandaran University of Medical Sciences

Designed & Developed by : Yektaweb