Burkitt’s lymphoma (BL) is a poorly differentiated B-cell lymphoma. It is rare and in Africa as well as occurs most often in children and young adults. In general, BL includes about 1-2 % of all lymphomas in adults, especially those under 35 years of age, and it can be highly malignant and progressive. Herein, we report a 34-year-old woman with complains of toothache. Followed by drainage of mandibular abscess, soft tissue mass appeared in left mandible that was removed by surgical excision and histopathology report confirmed the diagnosis of BL. CT scan findings revealed involvement of abdominopelvic cavity organs, breast and orbital cavity. This type of tumor is very progressive, therefore, early detection and immediate treatment by accurate imaging could help to determine the extent of tumor.