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Background and purpose: Labor induction is now one of the most common methods in the field of Obstetrics and Gynecology for cervix preparedness and entering the active phase of labor. This study was conducted to compare the effects of misoprostol and oxytocin. Materials and methods: This study was a double-blind clinical trial by recruitments of 60 primiparous women who referred to BooAli Hospital in Tehran, 2011. The participants were divided into control and intervention groups by random allocation. Misoprostol and oxytocin by four hour intervals were prescribed for those in pregnancy termination stage in order to induce labor. Results: The mean age and standard deviation in intervention and control group was 24 ± 3.96 and 24.1 ± 3.97, respectively. The main reasons for admission were postdate pregnancy and lack of labor pain. A significant correlation was found between treatment variables, cause of hospitalization, hypertension history and increased or decreased time to achieve regular and suitable contractions for delivery (P<0.05). Results showed no significant difference in two groups until three hours after treatment. However, a better influence of misoprostol was observed among the intervention group (P=0.014). Conclusion: In order to reduce time to reach short and effective contractions using misoprostol in labor induction is more effective than oxytocin. However, the two drugs did not show any significant differences regarding pregnancy outcomes including meconium passage, fetal distress and premature rupture of membrane.

Keywords: Labor induction, Misoprostol, Oxytocin, Bishop Score

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