Volume 28, Issue 168 (1-2019)                   J Mazandaran Univ Med Sci 2019, 28(168): 50-58 | Back to browse issues page

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Golchin S, Hedayatizadeh-Omran A, Alizadeh-Navaei R, Mokhberi V, Omrani-Nava V, Amjadi O et al . Association between MTHFR Gene Polymorphism (C677T) and Coronary Artery Disease . J Mazandaran Univ Med Sci. 2019; 28 (168) :50-58
URL: http://jmums.mazums.ac.ir/article-1-12306-en.html
Abstract:   (1327 Views)
Background and purpose: Coronary artery disease (CAD) is a complex disease that is caused by both environmental and genetic factors. Methylenetetrahydrofolate (MTHFR) enzyme is associated with metabolism of homocysteine and its impaired function is considered as a risk factor for developing CAD. Some variants are involved in decreased activity of MTHFR and its deficiency. The polymorphism of C677T (rs1801133) seems to be a significant variant that is related with CAD. The purpose of this study was to determine the relationship between MTHFR C677T gene polymorphism and susceptibility of CAD.
Materials and methods: This case-control study was performed in 71 patients with coronary artery disease and 71 healthy subjects (control group). Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was used to genotype MTHFR polymorphism.
Results: The mean ages of subjects in case and control groups were 58.2±8.9 and 46±13.9 years, respectively (P= 0.0000). The case group included 37 (52.1%) males and 34 (47.9%) females. In control group, there were 38 (53.5%) males and 33 (46.5%) females. The frequency of CC, CT, and TT genotypes in C677T polymorphisms was 59.2%, 35.2%, and 5.6%, in CAD patients and 62%, 32.4%, and 5.4%, in controls, respectively, indicating no significant differences between the cases and controls
(p= 0.937). The frequency of T allele was 40.8% in cases and 38% in controls which also showed no significant difference between the two groups (P= 0.864).
Conclusion: Current study found no relationship between MTHFR C677T gene polymorphism and CAD. However, further studies in larger population are recommended to achieve better understand this relationship.
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Type of Study: Research(Original) | Subject: Hematology and Oncology

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