Association between polymorphism of interleukin 17 (IL-17F) and increased susceptibility to gastric cancer - Journal of Mazandaran University of Medical Sciences
Volume 22, Number 91 (8-2012)                   J Mazandaran Univ Med Sci 2012, 22(91): 11-20 | Back to browse issues page


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Ghorbani A, Hosseini V, Ajami A, Rafiei A, Hosseini-khah Z, Janbabai G. Association between polymorphism of interleukin 17 (IL-17F) and increased susceptibility to gastric cancer. J Mazandaran Univ Med Sci. 2012; 22 (91) :11-20
URL: http://jmums.mazums.ac.ir/article-1-1340-en.html

Abstract:   (10290 Views)
Background and purpose: Gastric cancer is one of the most common gastrointestinal cancers in the world. Gastric cancer is the most common cancer in north of Iran. Interleukin-17F (IL-17F) is a pro-inflammatory cytokine expressed by a novel subset of CD4+ Th cells (Th-17), and it causes the occurrence and strengthening the inflammatory response. This study aimed to assess the association between IL-17F- A7488G polymorphism and potential susceptibility to gastric cancer. Materials and methods: A case-control study consisting of 161 gastric cancer patients with mean age 62.14 ± 12.6 and 171 healthy controls with mean age 58.93 ± 14.2 was conducted. Genomic DNA was extracted and genotypes of - A7488G polymorphism were assessed through polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: The frequency of G allele was higher in gastric cancer patients (12.1%) compared with the control group (9.15%), but these differences were not significant (P═0.22). In addition, the distribution of GG genotype was not significantly differed between the patients and the controls (4.3% vs. 1.8%, P=0.182). Furthermore, logistic regression analysis revealed no significant association between the presence of 7488G allele and clinical stages (P=0.28), tumor grade (P=0.36) and H. pylori infection (P=0.89). Conclusion: These results suggest that IL-17F A7488G polymorphism in the promoter of IL-17F gene is not directly assumed as a genetic risk factor in the predisposition to gastric cancer.
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Type of Study: Research(Original) |

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