Volume 22, Issue 95 (12-2012)                   J Mazandaran Univ Med Sci 2012, 22(95): 19-27 | Back to browse issues page

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Rafiei A, Khajavi R, Haghshenas M R, Hosseini-khah Z, Farazmandfar T, Sharbafi R. Association between Interleukin-28B Genetic Variants and Hepatitis C . J Mazandaran Univ Med Sci. 2012; 22 (95) :19-27
URL: http://jmums.mazums.ac.ir/article-1-1504-en.html
Abstract:   (13656 Views)
Background and purpose: Host genetic and environmental factors and factors associated with hepatitis C virus (HCV) play critical roles in development of the hepatitis. This study was performed to investigate the association between Interleukin-28B (IL-28B) genetic variants and chronic hepatitis C. Materials and methods: This case-control study was conducted in 133 HCV-RNA positive patients attending two methadone treatment clinics, a hemophilia center, a thalassemia center and three dialysis center in Mazandaran province, Iran, 2010-2011. In addition, 173 HCV negative subjects were recruited as the controls. The two groups were matched for age, sex and geographic region. The IL-28B genotype at polymorphic site rs12979860 was determined by Tetra-ARMS-PCR method. Quantitative and qualitative data were analyzed using Student t and Chi square tests, respectively. Results: The mean age of patients with HCV (96 male, 27 female) was 36.38 ± 12.49 years. The control group comprised 107 male and 66 female with the mean age of 38.27 ± 11.27 years. The distribution of IL-28B genotypes did not differ between the two groups (P=0.008). On the other hand, the frequency of C/C, C/T and T/T genotypes were 41.4, 41.6 and 17.3% in experimental group and 42.5, 40.6, and 16.9% in the control group, respectively. The frequency of C and T alleles was not significantly different between the two groups (P=0.84). Conclusion: No significant difference was observed in the frequency of the rs12979860 polymorphism in upstream of IL-28B among HCV patients and control groups. According to the proven role of C allele in association with HCV treatment response it is assumed that genetic differences in IL-28B or IFN-λ could predict treatment outcome.
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Type of Study: Research(Original) | Subject: Immunology

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