Volume 22, Issue 95 (12-2012)                   J Mazandaran Univ Med Sci 2012, 22(95): 10-17 | Back to browse issues page

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Karam Sichani2 S, Naghsh N, Razm N. Effects of Alcoholic Extract of Peganumharmala L. on Malondialdehyde Concentration and Catalaseand Glutathione Peroxidase Activity in Mice Treated with Nanosilver Particles. J Mazandaran Univ Med Sci. 2012; 22 (95) :10-17
URL: http://jmums.mazums.ac.ir/article-1-1509-en.html
Abstract:   (11485 Views)
Background and purpose: Nanosilver particles are associated with oxidative stress due to free radical production. Long-term use of antioxidant agents could result in harmful production of free radicals. This study assessed the protective and antioxidant effects of Peganumharmala L.onmalemicetreated with nanosilver particles. Materials and methods: In this study 32 male Albino mice (25-30gr) were divided into four groups one control group and three intervention groups. The intervention groups included a group receiving 500 ppm nanosilver particles, a group fed 20 mg/kg/day by ethanolic extract of P.harmalafor 30 days, and a group which was given ethanolic extract of P.harmalaorally and the same dose of nanosilver particles. Onthreeconsecutive day sat the beginning of the experiment intraperitoneal injections of nanosilver were performed. Post-treatment blood samples were collectedfromthe hearts and the activity of serum catalase (CAT) and glutathioneperoxidase (GPx) I nredblood cell and concentration of serummalondialdehyde (MDA) were determined. Results: In the mice treated with nanosilver particles the MDA concentration significantly increased, while significant decreases were seen in GPx and CAT activities (P<0.001). However, P.harmalaextract reversed these effects i.e. it increased GPx and CAT activities and decreased the MDA level significantly (P<0.001). Conclusion: The ethanolic extract of P. harmalawith antioxidant properties is believed to decrease thefreeradicals produced by silvernanoparticles.
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Type of Study: Research(Original) |

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