Volume 36, Issue 262 (Special Issue 2026)
J Mazandaran Univ Med Sci 2026, 36(262): 142-152 |
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Ghasemi S H, Hajiebrahimi N, Aghajanimir M, Mehdi Darzi M, Shirafkan H, Moudi E et al . Association Between Opium Consumption and Lower Urinary Tract Symptom Severity, Prostate Volume, and PSA Levels in Men Aged Over 60 Years. , J Mazandaran Univ Med Sci. 2026; 36 (262) :142-152
URL: http://jmums.mazums.ac.ir/article-1-22699-en.html
URL: http://jmums.mazums.ac.ir/article-1-22699-en.html
Seyyed Hosein Ghasemi 
, Nazanin Hajiebrahimi , Mohammadreza Aghajanimir , Mohammad Mehdi Darzi , Hoda Shirafkan , Emaduddin Moudi * , Abazar Akbarzadeh Pasha
, Nazanin Hajiebrahimi , Mohammadreza Aghajanimir , Mohammad Mehdi Darzi , Hoda Shirafkan , Emaduddin Moudi * , Abazar Akbarzadeh Pasha
Abstract: (51 Views)
Background and purpose: Lower urinary tract symptoms (LUTS) include symptoms such as urinary frequency, urgency, weak stream, and incontinence, which can seriously affect patients’ quality of life. Opium addiction, through its effects on the nervous system and bladder muscle function, may contribute to these symptoms. This study aimed to compare the frequency of LUTS between men with and without opium addiction aged over 60 years.
Materials and methods: This analytical cross-sectional study included 206 men aged over 60 years who presented to urology clinics with urinary symptoms at Babol University of Medical Sciences and Golestan University of Medical Sciences during 2022-2023. Patients were divided into opium-addicted and non-addicted groups. Urinary symptom severity was assessed using the International Prostate Symptom Score (IPSS), and the two groups were compared.
Results: Of 206 men with urinary symptoms, 90 were opium-addicted and 116 were non-addicted. The mean IPSS was 12.09±4.43 in the addicted group and 11.48±3.49 in the non-addicted group, with no significant difference (P=0.49). The total LUTS score (the sum of the six IPSS questions excluding nocturia; range 0–30) was significantly higher in the addicted group (10.8±3.99) than in the non-addicted group (5.48±3.50) (P<0.001). The distribution of symptom severity based on IPSS categories differed significantly between the two groups (P<0.001). The mean prostate volume was significantly higher in the addicted group (49.95±11.78 mL) than in the non-addicted group (34.38±10.72 mL) (P<0.001). The mean PSA level was significantly higher in the addicted group (2.66±0.17 ng/mL) than in the non-addicted group (1.72±0.13 ng/mL) (P<0.001).
Conclusion: Opium use was significantly associated with prostate volume, PSA level, and lower urinary tract symptoms. Therefore, screening for and management of LUTS should be considered in older men with opium addiction
Materials and methods: This analytical cross-sectional study included 206 men aged over 60 years who presented to urology clinics with urinary symptoms at Babol University of Medical Sciences and Golestan University of Medical Sciences during 2022-2023. Patients were divided into opium-addicted and non-addicted groups. Urinary symptom severity was assessed using the International Prostate Symptom Score (IPSS), and the two groups were compared.
Results: Of 206 men with urinary symptoms, 90 were opium-addicted and 116 were non-addicted. The mean IPSS was 12.09±4.43 in the addicted group and 11.48±3.49 in the non-addicted group, with no significant difference (P=0.49). The total LUTS score (the sum of the six IPSS questions excluding nocturia; range 0–30) was significantly higher in the addicted group (10.8±3.99) than in the non-addicted group (5.48±3.50) (P<0.001). The distribution of symptom severity based on IPSS categories differed significantly between the two groups (P<0.001). The mean prostate volume was significantly higher in the addicted group (49.95±11.78 mL) than in the non-addicted group (34.38±10.72 mL) (P<0.001). The mean PSA level was significantly higher in the addicted group (2.66±0.17 ng/mL) than in the non-addicted group (1.72±0.13 ng/mL) (P<0.001).
Conclusion: Opium use was significantly associated with prostate volume, PSA level, and lower urinary tract symptoms. Therefore, screening for and management of LUTS should be considered in older men with opium addiction
Keywords: Urinary frequency, urgency, weak stream, urinary incontinence, opium addiction, elderly men, International Prostate Symptom Score (IPSS)
Type of Study: Research(Original) |
Subject:
urology
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