Volume 36, Issue 261 (10-2026)
J Mazandaran Univ Med Sci 2026, 36(261): 195-207 |
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Nasiri Formi E, Tabatabaei Aghda J, Tabatabaei Aghda A. Effect of Arnebia euchroma Extract on Wound Healing: A Systematic Review of Human Clinical Evidence. J Mazandaran Univ Med Sci 2026; 36 (261) :195-207
URL: http://jmums.mazums.ac.ir/article-1-23092-en.html
URL: http://jmums.mazums.ac.ir/article-1-23092-en.html
Abstract: (23 Views)
Background and purpose: has traditionally been used for wound management; however, its clinical efficacy has not been comprehensively established. This systematic review aimed to critically evaluate the effects of topical A. euchroma extract on cutaneous wound healing and wound-related symptoms in humans.
Materials and methods: This systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and was registered in PROSPERO (CRD42024593713). International and domestic electronic databases were systematically searched from inception, without date restrictions. Interventional and non-randomised human studies comparing topical A. euchroma extract with placebo or standard treatment were eligible. The primary outcomes were wound size reduction, pain, inflammation, irritation, and healing time. Methodological quality and risk of bias were assessed using the Cochrane Risk of Bias 2 (RoB 2) tool for randomised clinical trials and the Joanna Briggs Institute (JBI) critical appraisal checklists for case series and case reports.
Results: Among 280 identified records, five studies involving 246 patients met the inclusion criteria, including three randomised controlled trials, one case series, and one case report. The types of wounds evaluated included burns, post-surgical wounds, post-CO₂ laser wounds, and chronic wounds. Most studies reported significantly greater reductions in wound size, pain, irritation, and inflammation among patients treated with A. euchroma compared with control interventions, including placebo and silver sulfadiazine. Nevertheless, one randomised controlled trial reported that Vaseline was associated with better outcomes than A. euchroma for post-CO₂ laser wounds.
Conclusion: Current evidence suggests that topical A. euchroma extract may accelerate wound healing and reduce wound-related symptoms, particularly in burns and post-surgical wounds. However, these findings should be interpreted cautiously because of substantial heterogeneity in study designs, wound characteristics, treatment protocols, and comparator groups, as well as the small number and limited quality of available clinical trials. Further well-designed, adequately powered randomised controlled trials are required to establish its clinical effectiveness and safety.
Materials and methods: This systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and was registered in PROSPERO (CRD42024593713). International and domestic electronic databases were systematically searched from inception, without date restrictions. Interventional and non-randomised human studies comparing topical A. euchroma extract with placebo or standard treatment were eligible. The primary outcomes were wound size reduction, pain, inflammation, irritation, and healing time. Methodological quality and risk of bias were assessed using the Cochrane Risk of Bias 2 (RoB 2) tool for randomised clinical trials and the Joanna Briggs Institute (JBI) critical appraisal checklists for case series and case reports.
Results: Among 280 identified records, five studies involving 246 patients met the inclusion criteria, including three randomised controlled trials, one case series, and one case report. The types of wounds evaluated included burns, post-surgical wounds, post-CO₂ laser wounds, and chronic wounds. Most studies reported significantly greater reductions in wound size, pain, irritation, and inflammation among patients treated with A. euchroma compared with control interventions, including placebo and silver sulfadiazine. Nevertheless, one randomised controlled trial reported that Vaseline was associated with better outcomes than A. euchroma for post-CO₂ laser wounds.
Conclusion: Current evidence suggests that topical A. euchroma extract may accelerate wound healing and reduce wound-related symptoms, particularly in burns and post-surgical wounds. However, these findings should be interpreted cautiously because of substantial heterogeneity in study designs, wound characteristics, treatment protocols, and comparator groups, as well as the small number and limited quality of available clinical trials. Further well-designed, adequately powered randomised controlled trials are required to establish its clinical effectiveness and safety.
Type of Study: Review |
Subject:
Reconstructive and Burn, Plastic surgery
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