Volume 15, Issue 50 (Jan 2006)                   J Mazandaran Univ Med Sci 2006, 15(50): 139-142 | Back to browse issues page

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Ënayati A, Ladonni H. Mixed function oxidases and insecticide resistance in medically important insects. J Mazandaran Univ Med Sci. 2006; 15 (50) :139-142
URL: http://jmums.mazums.ac.ir/article-1-725-en.html
Abstract:   (30317 Views)
MFÔs are a large diverse superfamily of enzymes found in all insect tissues. They are involved in the metabolism of xenobiotics (e.g. drugs, pesticides and plant toxins) and endogenous compounds (e.g. ecdysteroids and juvenile hormones). They are also involved in bioactivation of phosphorothioate compounds such as organophosphorus insecticides. They have very diverse activities like hydroxylation, epoxidation, N-, Ô-or S-dealkylation, deamination, sulfoxidation, desulfuration and oxidative dehalogenation. Their diverse functions are achieved through diversity in structure. There are over 100 P450 genes in the Drosophila genome, usually arranged in family clusters. MFÔ-mediated insecticide metabolism is a common mechanism by which insects become resistant to insecticides. Ïn this mini review article the role of oxidases in insecticide resistance is briefly discussed.
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Type of Study: Research(Original) |

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