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Background and purpose: Multiple sclerosis (MS) is a disorder of the central nervous system and is rarely accompanied with seizure. The purpose of this study is to determine the frequency of different types of MS in patients with and without seizure. Materials and methods: A descriptive cross-sectional study was carried out on MS patients in Guilan from 2008-2010. The information regarding the demography of patients and the type of their MS were collected and then data were analyzed by χ 2, T- test and logistic regression using SPSS17. Results: From the total of 209 MS patients in this study (74.1% female and 25.9% male), 13 patients (69.2% female and 30.8% male) had seizure. The means of patients’ age, the age of disorder onset and EDSS in groups with & without seizure were 34.0 ± 8.6 and 33.2 ± 9.8 years, 26.18 ± 11.80 and 27.96 ± 8.05 years and 4.2 ± 2.5 and 4.6 ± 1.5 respectively. All these means between two groups were not significantly different. The prevalence of relapsing-remitting (RRMS), secondary (SPMS) and primary progressive MS (PPMS) in patients without seizure was 80.1%, 11.7% and 8.2% and in group with seizure was 38.5%, 53.8% and 7.7%, respectively and the difference was statistically significant. The seizure increases the probability of SPMS by 8.94-fold (95%CI: 2.51-31.77) and decreases the probability of RRMS by 10.16-fold (95% CI: 1.96-28.57). Also SPMS increases the chance of seizure by 10.16-fold (95% CI 2.65-38.88) compared with SPMS. Conclusion: SPMS is more prevalent in MS patients with seizure and seizure is a positive predictor for MS progression.

Keywords: Multiple sclerosis, seizure, relapsing-remitting, primary progressive, secondary progressive

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