Volume 27, Issue 148 (5-2017)                   J Mazandaran Univ Med Sci 2017, 27(148): 1-11 | Back to browse issues page

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Karimifar K, Alipanah H, Bigdeli M R. Effect of Viola odorata Extract on Reducing Infarct Volume and Neurological Defects in Focal Cerebral Ischemia Animal Model . J Mazandaran Univ Med Sci. 2017; 27 (148) :1-11
URL: http://jmums.mazums.ac.ir/article-1-9948-en.html
Abstract:   (3631 Views)

Background and purpose: Cerebral ischemia is a general injury characterized by direct tissue damage and increasing free radicals that leads to the death of brain tissue, cerebral infarction, or ischemic stroke. Some studies have demonstrated anti-inflammatory, antipyretic and antibacterial activities of Viola odorata. However, key aspects of the effect of Viola odorata in stroke are scarce. This study investigated the effect of Viola odorata extract (VOE) on neurological deficit scores (NDS) and infarct volume (IV) in MCAO stroke model.

Materials and methods: In this experimental study, 20 male Wistar rats weighing 200 to 300 g were assigned to 4 groups including three treatment groups and control group. After preparation of VOE, the experimental groups received different doses of VOE (25, 50 and 75 mg/kg) by gastric gavage while the control group received distilled water for 30 days by gastric gavage. Two hours after the last gavage, the rats were exposed to 60 min MCAO surgery and 24 hours later, the IV and NDS were evaluated.

Results: Compared with the control group, reduction was seen in total IV and NDS in animals treated with VOE50. Investigation of IV in the core, penumbra and subcortex of right hemisphere demonstrated that VOE25 and VOE50 decreased IV in the subcortex and core regions, and just VOE50 decreased IV in the penumbra during the treatment. VOE75 decreased IV only in the subcortex region.

Conclusion: Although further studies are needed to clarify the mechanism of Viola odorata, the present study explored the potential effect of Viola odorata extract on reducing infarct volume and neurological defects in MCAO stroke model. This study could be helpful for future exploration of protective effect of V. odorata on cerebral ischemia.

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Type of Study: Research(Original) |

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