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Background and purpose: One of the factors affecting quality of life is health and illness. Including diseases that affect quality of life is tuberculosis. This study was done in order to evaluated quality of life patients with pulmonary tuberculosis during treatment course Materials and methods: This study is a cross-sectional study that was done in 1390 on 50 patients with pulmonary tuberculosis covered by health centers in Zahedan during three stage of treatment (beginning of treatment, end of attack stage, end of maintenance phase). Samples were chosen to participate in the study by accessible sampling. TBQOL-Version 2 was used to data collection. Data were analyzed by correlation coefficient, independent t, and ANOVA tests. Results: The majority of subjects (68%) were Female with mean age of 58.60 ± 17.50 years. Results showed that the mean overall quality of life scores of 66.6 at the beginning of treatment to 92.4 at the end of attack stage and 102.5 in the end of maintenance phase is increased (maximum score was 120). Also finding showed significant increases in quality of life scores in physical, psychological, functional, environment and spiritual dimensions during three stages of treatment but significant increases in mean score on the social and family health were not observed Conclusion: In addition, treatment of pulmonary tuberculosis control disease and reduce of symptoms, it can promote quality of life patients particularly in physical, psychological, functional, environment and spiritual dimensions. Thus the importance of complete treatment for tuberculosis should be emphasized more than before

Keywords: Stage of treatment, pulmonary tuberculosis, quality of life

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