Volume 33, Issue 1 (11-2023)                   J Mazandaran Univ Med Sci 2023, 33(1): 25-35 | Back to browse issues page

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Hosseinzadeh M, Abbasi Daloii A, Hoseini S A, Abdi A. The Effects of Aerobic Training and Garlic Supplementation on Superoxide Dismutase, Glutathione Peroxidase and Malondialdehyde of Brain Tissue in Aged Rats with Parkinson’s Disease. J Mazandaran Univ Med Sci 2023; 33 (1) :25-35
URL: http://jmums.mazums.ac.ir/article-1-19717-en.html
Abstract:   (345 Views)
Background and purpose: Disorder in the brain oxidant-antioxidant system is the main cause of neurodegenerative diseases. Although the favorable effects of exercise and garlic supplementation on nervous system disorders are known, but their interactive effect is not well known. Therefore, the aim of the present study was to determine the effects of aerobic training and garlic supplementation on superoxide dismutase, glutathione peroxidase and malondialdehyde of brain tissue in aged rats with Parkinson’s disease.
Materials and methods: 40 Sprague-Dawley male rats (weight 250±20 gr) were randomly divided into five groups (1) healthy control, (2) Parkinson's control, (2) Parkinson's- aerobic exercise, (3) Parkinson's- garlic supplement and (5) Parkinson's-aerobic exercise-garlic supplement. In this study, rats were infected with Parkinson's disease by injecting 2 mg/kg of reserpine. Aerobic training was performed five sessions a week and each session lasted 15-48 minutes at speed of 10-24 meters per minute, for eight weeks. Supplement groups received daily 500 mg/kg garlic by gavage. Data were analyzed by one-way analysis of variance and Tukey post hoc test at the P<0.05.
Results: The activity of GPx and MDA in the Parkinson's-supplemented garlic, Parkinson's-aerobic exercise and Parkinson's-aerobic exercise-supplemented garlic groups was higher than the Parkinson's control group (P≥0.05). The activity of SOD in the Parkinson's - aerobic exercise - garlic supplementation group were higher than the Parkinson's control group (P≥0.05). SOD was significantly higher in the aerobic exercise and Parkinson's-aerobic exercise-garlic supplementation than the Parkinson's-garlic supplementation group, and it was significantly higher the in the Parkinson's group-aerobic exercise-garlic supplement than the Parkinson's group-aerobic exercise (P≥0.05).
Conclusion: It seems that aerobic exercise with garlic supplement can help improve antioxidants and reduce oxidative stress in the brain tissue of rats with Parkinson's disease.

 
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Type of Study: Research(Original) | Subject: Sport Physiology

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