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Background and purpose: From many years ago denture adhesives have been used to improve denture’s performance. During the time, many new formulations have been prepared and evaluated to improve the properties of this product. In this study, the powder form of this product was prepared then in vitro and in vivo evaluations were performed. Material and Methods: To design the denture adhesive powder, sodium alginate, plantagopsyllium mucilage and sodium carboxy methyl cellulose were used as the main binding agents. Different formulations with different ratio of these three agents were prepared, then, their binding strength and duration of efficacy were evaluated in the lab. Finally, the best formulation was chosen for in vivo evaluation. Results: The study showed that prepared formulations containing sodium alginate and NaCMC with ratio of 95:5 had higher binding strength ability and duration of efficacy than artificial saliva. This formulation also had positive effect on the performance of denture during eating and speaking and also prolonged the adhesion period of denture. No significant differences were seen between this formulation and protefix in performance properties but in other properties like odor and flavor the prepared product were found better than protefix. Conclusion: This experimental study showed that the mixture of sodium alginate and NaCMC with more ratio of alginate 95:5 is a proper product to be used as a denture adhesive.

Keywords: adhesive, sodium alginate, sodium carboxy methyl cellulose, binding strength

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