Volume 29, Issue 174 (7-2019)
J Mazandaran Univ Med Sci 2019, 29(174): 22-29 |
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Kamrani G, Montazer F, Nejadi Keralirjani F, Shekarriz R. Expression of Aldehyde Dehydrogenase 1 in Patients with Colorectal Cancer in North of Iran
. J Mazandaran Univ Med Sci 2019; 29 (174) :22-29
URL: http://jmums.mazums.ac.ir/article-1-13201-en.html
URL: http://jmums.mazums.ac.ir/article-1-13201-en.html
Abstract: (3030 Views)
Background and purpose: High cancer related mortality can be due to the presence of cancer stem cells (CSCs). Studies suggest aldehyde dehydrogenase (ALDH1) as a marker of CSCs. The aim of this study was to investigate its expression in colorectal cancer and also its association with clinicopathologic characteristics.
Materials and methods: In a retrospective study, patients with colorectal cancer attending Sari Imam Khomeini Hospital were enrolled. The intensity and distribution of ALDH1 expression in tumor and non-tumoral adjacent tissue samples were measured by immunohistochemistry. Data were analyzed using SPSS V18.
Results: Forty patients including 20 males and 20 females were studied. The frequency and intensity of ALDH1 expression in tumoral and non-tumoral tissues were not significantly different. The expression intensity was not related to age, type of adenocarcinoma, and tumor location, but it was found to be higher in women (P=0.08). Mild ALDH1 expression was higher in well-differentiated grade (P= 0.07). Discontinuous distribution was higher in non-mucinous adenocarcinoma (P= 0.06) and well-differentiated grade (P= 0.028).
Conclusion: In this study, ALDH1 expression was not significantly different in the samples of colorectal cancer and normal adjacent. But, higher intensity of expression in women and discontinuous distribution were observed in well-differentiated and non-mucinous samples. The role of ALDH1 as a CSC marker in colorectal cancer requires further investigations.
Materials and methods: In a retrospective study, patients with colorectal cancer attending Sari Imam Khomeini Hospital were enrolled. The intensity and distribution of ALDH1 expression in tumor and non-tumoral adjacent tissue samples were measured by immunohistochemistry. Data were analyzed using SPSS V18.
Results: Forty patients including 20 males and 20 females were studied. The frequency and intensity of ALDH1 expression in tumoral and non-tumoral tissues were not significantly different. The expression intensity was not related to age, type of adenocarcinoma, and tumor location, but it was found to be higher in women (P=0.08). Mild ALDH1 expression was higher in well-differentiated grade (P= 0.07). Discontinuous distribution was higher in non-mucinous adenocarcinoma (P= 0.06) and well-differentiated grade (P= 0.028).
Conclusion: In this study, ALDH1 expression was not significantly different in the samples of colorectal cancer and normal adjacent. But, higher intensity of expression in women and discontinuous distribution were observed in well-differentiated and non-mucinous samples. The role of ALDH1 as a CSC marker in colorectal cancer requires further investigations.
Keywords: cancer stem cell, aldehyde dehydrogenase, colorectal cancer, clinicopathologic characteristics
Type of Study: Research(Original) |
Subject:
Pathology
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