Volume 34, Issue 241 (1-2025)
J Mazandaran Univ Med Sci 2025, 34(241): 12-28 |
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Barani A, Asadollahzadeh Asl A, Eslami C, Hashemi P, Goli H R, Ebrahimzadeh M A. Overcoming Drug Resistance and Removing Water Pollutant Dyes Using Cobalt Nanoparticles Synthesized via the Green Synthesis Method with Mentha pulegium Plant Extract. J Mazandaran Univ Med Sci 2025; 34 (241) :12-28
URL: http://jmums.mazums.ac.ir/article-1-21211-en.html
URL: http://jmums.mazums.ac.ir/article-1-21211-en.html
Amin Barani 
, Alireza Asadollahzadeh Asl , Cyrus Eslami , Parastoo Hashemi , Hamid Reza Goli , Mohammad Ali Ebrahimzadeh
, Alireza Asadollahzadeh Asl , Cyrus Eslami , Parastoo Hashemi , Hamid Reza Goli , Mohammad Ali Ebrahimzadeh
Abstract: (594 Views)
Background and purpose: Due to the increasing importance of protecting human health and preserving the environment, drug resistance and water pollution have drawn significant attention. Nanoparticles have emerged as one of the most promising solutions, with cobalt nanoparticles being particularly interesting due to their unique properties. This study focuses on the green synthesis of cobalt nanoparticles using Mentha pulegium and investigates their potential antimicrobial and photocatalytic activities.
Materials and methods: n this experimenal study, cobalt nanoparticles were synthesized through green methods using M. pulegium aqueous extract. The synthesized nanoparticles were characterized using various analytical techniques, including UV-visible spectroscopy, SEM, EDX, FTIR, and XRD. Furthermore, the antibacterial effects of these nanoparticles were investigated against ATCC strains and ciprofloxacin-resistant strains. Their photocatalytic activity was evaluated for the degradation of methylene blue (MB) in the presence of NaBH4.
Results: XRD analysis revealed that the synthesized nanoparticles were amorphous, while SEM images showed irregularly shaped particles with an average diameter of 53.91 nm. The cobalt nanoparticles demonstrated excellent antibacterial activity. The maximum antibacterial effects were observed against ATCC strains, specifically K. pneumoniae (MIC and MBC values of 0.859 and 13.75 μg/mL, respectively) and S. aureus (MIC and MBC values of 1.72 and 27.5 μg/mL, respectively). For ciprofloxacin-resistant strains, the maximum effects were observed against E. coli (MIC and MBC values of 0.859 and 6.87 μg/mL, respectively) and P. mirabilis (MIC and MBC values of 0.859 and 1.72 μg/mL, respectively). These nanoparticles efficiently degraded methylene blue in the presence of NaBH4 within 30 minutes, following first-order kinetics with a rate constant of 0.0567 min-¹.
Conclusion: The results showed that M. pulegium effectively contributed to the formation of nanoparticles, acting as a reducing, stabilizing, and capping agent. In this study, the synthesized cobalt nanoparticles exhibited significant antibacterial activity and effective dye degradation properties. These findings suggest the potential application of cobalt nanoparticles in various biological fields.
Materials and methods: n this experimenal study, cobalt nanoparticles were synthesized through green methods using M. pulegium aqueous extract. The synthesized nanoparticles were characterized using various analytical techniques, including UV-visible spectroscopy, SEM, EDX, FTIR, and XRD. Furthermore, the antibacterial effects of these nanoparticles were investigated against ATCC strains and ciprofloxacin-resistant strains. Their photocatalytic activity was evaluated for the degradation of methylene blue (MB) in the presence of NaBH4.
Results: XRD analysis revealed that the synthesized nanoparticles were amorphous, while SEM images showed irregularly shaped particles with an average diameter of 53.91 nm. The cobalt nanoparticles demonstrated excellent antibacterial activity. The maximum antibacterial effects were observed against ATCC strains, specifically K. pneumoniae (MIC and MBC values of 0.859 and 13.75 μg/mL, respectively) and S. aureus (MIC and MBC values of 1.72 and 27.5 μg/mL, respectively). For ciprofloxacin-resistant strains, the maximum effects were observed against E. coli (MIC and MBC values of 0.859 and 6.87 μg/mL, respectively) and P. mirabilis (MIC and MBC values of 0.859 and 1.72 μg/mL, respectively). These nanoparticles efficiently degraded methylene blue in the presence of NaBH4 within 30 minutes, following first-order kinetics with a rate constant of 0.0567 min-¹.
Conclusion: The results showed that M. pulegium effectively contributed to the formation of nanoparticles, acting as a reducing, stabilizing, and capping agent. In this study, the synthesized cobalt nanoparticles exhibited significant antibacterial activity and effective dye degradation properties. These findings suggest the potential application of cobalt nanoparticles in various biological fields.
Keywords: drug resistance, cobalt nanoparticles, green synthesis, photocatalytic activity, antibacterial activity, Mentha pulegium
Type of Study: Research(Original) |
Subject:
Nano technology
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