Volume 35, Issue 251 (12-2025)
J Mazandaran Univ Med Sci 2025, 35(251): 235-252 |
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Saghiriganjeh M, Hakiminia B, Poorali K, Hosseinzadeh E, Salarian S. The Neuroprotective Role of Coenzyme Q10 in Neurological Disorders: A Narrative Review. J Mazandaran Univ Med Sci 2025; 35 (251) :235-252
URL: http://jmums.mazums.ac.ir/article-1-22158-en.html
URL: http://jmums.mazums.ac.ir/article-1-22158-en.html
Abstract: (31 Views)
Background and purpose: Neurological disorders, including chronic neurodegenerative diseases and acute brain injuries, are among the leading causes of cognitive and motor disabilities worldwide. Oxidative stress and mitochondrial dysfunction are key mechanisms in the occurrence of these brain disorders. Due to the potent antioxidant properties of coenzyme Q10 (CoQ10) and its critical role in maintaining mitochondrial function, research has been conducted on its effects in neurological disorders.
This review examines findings from laboratory studies, animal models, and clinical trials concerning the potential benefits of CoQ10 in various neurodegenerative diseases, such as Parkinson's disease, Alzheimer's disease, Huntington's disease, and amyotrophic lateral sclerosis, as well as in acute neurological conditions like acute ischemic stroke and traumatic brain injury.A search was conducted in the PubMed, Scopus, Web of Science, and Google Scholar databases up until October 2025, using relevant keywords. CoQ10 is present in the inner membrane of mitochondria and plays a key role in cellular energy production as an electron carrier in the electron transport chain. According to the results of previous studies, decreased levels of CoQ10 in neurological disorders have been associated with increased markers of oxidative stress, impaired mitochondrial function, and ultimately increased neuronal degeneration. Numerous studies in various models have demonstrated the neuroprotective effects of CoQ10, primarily through reducing oxidative stress, enhancing mitochondrial function, and inhibiting cell death. Furthermore, human studies have confirmed that CoQ10 is safe and well-tolerated as a supplement. Despite the promising results from animal studies, further well-designed clinical trials are needed to confirm the efficacy of CoQ10 in treating human neurological disorders.
This review examines findings from laboratory studies, animal models, and clinical trials concerning the potential benefits of CoQ10 in various neurodegenerative diseases, such as Parkinson's disease, Alzheimer's disease, Huntington's disease, and amyotrophic lateral sclerosis, as well as in acute neurological conditions like acute ischemic stroke and traumatic brain injury.A search was conducted in the PubMed, Scopus, Web of Science, and Google Scholar databases up until October 2025, using relevant keywords. CoQ10 is present in the inner membrane of mitochondria and plays a key role in cellular energy production as an electron carrier in the electron transport chain. According to the results of previous studies, decreased levels of CoQ10 in neurological disorders have been associated with increased markers of oxidative stress, impaired mitochondrial function, and ultimately increased neuronal degeneration. Numerous studies in various models have demonstrated the neuroprotective effects of CoQ10, primarily through reducing oxidative stress, enhancing mitochondrial function, and inhibiting cell death. Furthermore, human studies have confirmed that CoQ10 is safe and well-tolerated as a supplement. Despite the promising results from animal studies, further well-designed clinical trials are needed to confirm the efficacy of CoQ10 in treating human neurological disorders.
Keywords: Alzheimer’s disease, Coenzyme Q10, Mitochondrion, Oxidative stress, Parkinson’s disease, Stroke, Traumatic brain injury
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