Volume 24, Issue 117 (10-2014)                   J Mazandaran Univ Med Sci 2014, 24(117): 21-28 | Back to browse issues page

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Hashemi S M J, Janbabai G, Hashemi Soteh S M B, Shekarriz R, Mahdavi M R, Ghaemian A et al . Investigating Factor V Leiden and Prothrombin G20210A Gene Mutation in Relation with Acute Myocardial Infarction. J Mazandaran Univ Med Sci 2014; 24 (117) :21-28
URL: http://jmums.mazums.ac.ir/article-1-4455-en.html
Investigating Factor V Leiden and Prothrombin G20210A Gene Mutation in Relation with Acute Myocardial Infarction
Seyyed Mohammad Javad Hashemi , Ghasem Janbabai , Seyyed Mohammad Bagher Hashemi Soteh , Ramin Shekarriz , Mohammad Reza Mahdavi , Ali Ghaemian , Nosrat Amini
Abstract:   (7980 Views)
Background and purpose: Beside the environmental determinants there are major genetic factors that could cause Myocardial Infarction (MI). The aim of this study was to clarify the relationship between factor V Leiden and prothrombin G20210A with acute MI in patients younger than 50 years of age. Materials and methods: In this case-control study we recruited 101 MI patients and 101 healthy individuals in Fatemeh Zahra Hospital, affiliated to Mazandaran University of Medical Sciences. Demographic information and risk factors including age, past history of MI, diabetes mellitus, hypertension, dyslipidemia, and smoking were recorded. Genes of factor V Leiden and prothrombin G20210A were analyzed using PCRRFLP method. Results: Among all subjects, 191 (94.55%) had no factor V Leiden gene, 10 (4.95 %) were heterozygous, and one (0.49%) was homozygous. In case group, and control group there were seven (6.9%) and three (2.97%) heterozygous for factor V Leiden, respectively (P= 0.27). There was no mutation of prothrombin G20210A gene in 197 (97.5%) individuals and only five (2.5%) were heterozygous. There was no statistically significant difference between the two groups (P= 0.17). Conclusion: The prevalence of factor V Leiden and prothrombin G20210A gene mutation, in patients was not significantly different from that of the normal individuals. However, further studies are recommended in this age group to investigate these factors.
Keywords: Myocardial infarction, factor V Leiden, prothrombin G20210A
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Type of Study: Research(Original) | Subject: genetic
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