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Background and purpose: Chronic immobilization stress induces the production of free radicals and oxidative stress. The aim of this study was to investigate the effect of royal jelly (RJ) as an antioxidant against oxidative stress induced by chronic immobilization stress in liver of male mice. Material and methods: In this research 30 male mice were randomly divided into 5 groups (n=6) including: 1.control group 2. rats subjected to 40 days of 2 hour immobilization stress daily, and groups 3, 4and 5 that were subjected to immobilization stress and also received royal jelly orally at the dose of 50,100 and 200 mg/kg body weight daily for 40 days, respectively. At the end of the treatment, blood was taken for biochemical analysis, and liver tissue was removed for histological studies and lipid peroxidation analysis. Data was analyzed by one way ANOVA and Tukey test in SPSS software. Results: In mice subjected to immobilization stress and royal jelly, the lipid peroxidation and levels of liver enzymes (ALT, AST) significantly decreased compared to the stress level in group 4. In histopathological studies royal jelly at dose of 50 and 100 improved immobilization stress induced by histopathological changes. But the dose of 200 mg/kg was not found very effective. Conclusion: The results indicate that administration of RJ at dose of 100 mg/kg promote histopathological changes in liver induced by immobilization stress.

Keywords: ChronicImmobilization stress, liver, male mice, royal jelly

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