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Background and purpose: Piroxicam is a non-steroidal anti- inflammatory drug that is characterized by low solubility and high permeability. According to the biopharmaceutic drug classification system, piroxicam is a class 2 drug with low solubility and high permeability. The solid dispersion, ammroach is commonly used to improve the dissolution of poorly water soluble drugs using hydrophilic polymeric carriers as dispersing agents. In this study, the solid dispersion of piroxicam were prepared with different carriers for improving the dissolution rate of the drug and also the physicochemical properties of solid dispersions were evaluated. Materials and methods: Piroxicam solid dispersions were prepared by hot melting and melting–solvent methods using PEG4000. The influence of tween 40 was also studied. The prepared solid dispersion properties of the drug were evaluated by dissolution studies, Differential scanning calorimetry (DSC), Fourier–transform infrared spectroscopy (FTIR), and X-ray powder diffraction (XRD). Results: The results showed a significant increase in dissolution rate of piroxicam from solid dispersions. Tween 40 also increased the dissolution rate of solid dispersions. XRD patterns indicated that piroxicam exists in its solid state in all solid dispersions. The DSC and FTIR results showed no chemical interaction between the drug and the polymer. Conclusion: This study showed significant improvements in dissolution rate of piroxicam solid dispersion prepared by PEG4000 and tween 40.

Keywords: Solid dispersion, piroxicam, Polyethylene Glycol 4000, tween 40, dissolution rate

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