Volume 10, Issue 27 (Jun 2000)
J Mazandaran Univ Med Sci 2000, 10(27): 48-53 |
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Baba Mahmoodi F. Evaluation of Hepatitis B Antibody (HBS) Levels in Nursing Staff Of Gaemshahr Razi Hospital and it’s Variation With Duration Of Immunity Post HB Vaccination. . J Mazandaran Univ Med Sci 2000; 10 (27) :48-53
URL: http://jmums.mazums.ac.ir/article-1-300-en.html
URL: http://jmums.mazums.ac.ir/article-1-300-en.html
Abstract: (40619 Views)
Background and Purpose : The prevalence of Hepatitis B in ÜSÂ was reported 0.5- 0.1 % while in Ïran is 1.6- 6.5 %. Ït was reported that the titer of antibody three days after vaccination was 79-90 %. The titer of antibody decreases with the pass of time, and age has a significant role in the respones to vaccination. This study was performed in order to evaluate the HBS titer after vaccination against hepatitis and the rate of its decline as time passes in the nursing staff of Gaemshahr Razi Hospital.
Materials and Methods: This was a Çross- sectional study, done on 183 nursing staff. 4cc blood was collected from each person at the same time vaccination was repeated. The history of vaccination was reported in a questionnaire paper by the same candidate. HBSÂg and HBSÂb were measured quantitatively with using Ëuro kit by ËLÏSÂ method.
Results: 1.6 % of staff were HBSÂg positive. 54.1%, 13.1% and 10.9% staff received vaccine three times, two times and once and 86%, 71% and, 55% of them had antibody titer more than 10 mu/ml respectively. 21.9% of them were not vaccinated, but 12.5% of them had antibody titer more than 10 mu/ml as time pass there was a decline in antibody titer. So that 94.1% of them in the first year declined to 67.8% in the next fifth year and the age above 40 years had a negative effect on antibody formation.
Çonclusion: Ôld age and numbers of vaccinations has a significant role in the responses to vaccine, and with time the titer of HBS antibody declines, so a booster dose should be considered.
Materials and Methods: This was a Çross- sectional study, done on 183 nursing staff. 4cc blood was collected from each person at the same time vaccination was repeated. The history of vaccination was reported in a questionnaire paper by the same candidate. HBSÂg and HBSÂb were measured quantitatively with using Ëuro kit by ËLÏSÂ method.
Results: 1.6 % of staff were HBSÂg positive. 54.1%, 13.1% and 10.9% staff received vaccine three times, two times and once and 86%, 71% and, 55% of them had antibody titer more than 10 mu/ml respectively. 21.9% of them were not vaccinated, but 12.5% of them had antibody titer more than 10 mu/ml as time pass there was a decline in antibody titer. So that 94.1% of them in the first year declined to 67.8% in the next fifth year and the age above 40 years had a negative effect on antibody formation.
Çonclusion: Ôld age and numbers of vaccinations has a significant role in the responses to vaccine, and with time the titer of HBS antibody declines, so a booster dose should be considered.
Keywords: Hepatitis B Surface antibody, Hepatitis B Vaccination, Nursing staff, Hepatitis B surface antigen
Type of Study: Research(Original) |
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